Journal: International Journal of Pharmaceutics: X
Article Title: Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability
doi: 10.1016/j.ijpx.2026.100551
Figure Lengend Snippet: In vivo pharmacokinetics in rats after nasal administration of aprepitant SFD formulations (20/80, HPC-UL or HPC-SSL, 10% solid content) compared to film-cast ASD formulations of identical composition. Data are presented as mean ( n = 3); error bars are omitted for clarity.
Article Snippet: Hydroxypropyl cellulose (HPC) grades HPC-SSL (viscosity 2.0–2.92.5 mPa·s in 2% aqueous solution at 20 °C) and HPC-UL (viscosity 1.7 mPa·s in 2% aqueous solution at 20 °C) were provided by Nippon Soda Co., Ltd. (Tokyo, Japan).
Techniques: In Vivo, Drug discovery